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李妍
2019-06-12 18:54   审核人:   (访问量)

    

    李妍,女,197812月生,澳门新葡8522最新网站细胞生物学副教授,硕士生导师。毕业于澳门新葡8522最新网站临床医学专业本科,遗传学硕士和细胞生物学博士,并在美国sanford-burham研究所进行博士后研究。主要研究方向是探讨肿瘤微环境下蛋白激酶作用及泛素连接酶在调控肿瘤免疫和肠道微生物中的作用。作为课题负责人,主持完成一项美国国防部 PRCRP基金,两项国家自然科学基金及一项省基金。发表文章在Nature Communication, Nucleic Acid ResearchBBA-Molecular Cell ResearchSCI杂志。

代表性论文:

1. Yan Li, Roberto Tinoco, Lisa Elmén, Igor Segota, Yibo Xian, Yu Fujita, Avinash Sahu, Raphy Zarecki, Kerrie Marie, Yongmei Feng, Ali Khateb, Dennie T. Frederick, Shiri K Ashkenazi, Hyungsoo Kim, Eva Guijarro Perez, Chi-Ping Day, Rafael S. Muñoz, Robert Schmaltz, Shibu Yooseph, Miguel A. Tam, Tongwu Zhang, Emily Avitan-Hersh, Lihi Tzur, Shoshana Roizman, Ilanit Boyango, Gil Bar-Sela, Amir Orian, Randal J. Kaufman, Marcus Bosenberg, Colin R Goding, Bas Baaten, Mitchell P. Levesque, Reinhard Dummer, Kevin Brown, Glenn Merlino, Eytan Ruppin, Keith Flaherty, Amanda Ramer-Tait, Tao Long, Scott N. Peterson, Linda M. Bradley, Ze’ev A. Ronai. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nature Communication. 2019, 10(1):1492. doi: 10.1038/s41467-019-09525-y

2. Yu Fujita, Roberto Tinoco, Yan Li, Daniela Senft, and Ze’ev A. Ronai. Ubiquitin ligases in autoimmunity and antitumor immunity. Trends in Molecular Medicine. 2019 Mar 18. pii: S1471-4914(19)30034-6. doi: 10.1016/j.molmed.

3. Yu Fujita, Ali Khateb, Yan Li, Roberto Tinoco, Tongwu Zhang, Haggai Bar-Yoseph, Miguel A. Tam, Yehuda Chowers, Edmond Sabo6, Shiran Gerassy-Vainberg, Elina Starosvetsky, Brian James, Kevin Brown, Shai S. Shen-Orr, Linda M. Bradley, Philippe A. Tessier, Ze’ev A. Ronai. Regulation of S100A8 stability by RNF5 in intestinal epithelial cells determines intestinal inflammation and severity of colitis. Cell Reports. 2018, 24(12): 3296-3311.

4. Yanshu Li, Hongyan Zhang, Yue Zhao, Chunyu wang, Zhenguo Chen, Lina Tang, Yunling Gao, Furong Liu, Jiabin Li, Yan Li, Yang Li, Nanxi Geng, Xue Rui, Yue-e Teng, Yunpeng Liu, Liu Cao, Rakesh Kumar, Feng Jin, Feng Li. A Mandatory Role of Nuclear PAK4-LIFR Axis in Breast-to-bone Metastasis of ERα-positive Breast Cancer Cells. Oncogene. 2018 Sep 3. doi: 10.1038/s41388-018-0456-0.

5. Yuxin Tong, Yan Li, Hui Gu, Chunyu Wang, Funan Liu, Yangguang Shao, Feng Li. HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells. BBA - Molecular Basis of Disease. 2018,1864(4 Pt A): 1104-1114.

6. Li Y, Shao YG, Tong YX, Shen T, Zhang J, Li YS, Gu H, Li F. Nucleo-cytoplasmic Shuttling of PAK4 Modulates intracellular translocation and signaling of β-catenin. BBA-Molecular Cell Research. 2012, 1823(2), 465-75.

7. Shen T, Li Y, Yang L, Xu X, Liang F, Liang S, Ba G, Xue F, Fu Q. Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. Int J Biochem Cell Biol. 2012, 44(2),423-429.

8. Shao YG#, Li Y# 共同一作, Zhang J, Liu D, Liu FR, Zhao Y, Shen T, Li F. Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX9. Nucleic Acids Research. 2010, 38(9), 2813-24.

9. Li CY#, Li Y# 共同一作, Li YH, Liu H, Sun ZJ, Lu JY, Zhao YY. Glucocorticoid repression of human with-no-lysine (K) kinase-4 gene expression is mediated by the negative response elements in the promoter. J Mol Endocrinol. 2008, 40(1),3-12.

10. Liu H, Zhao Y, Nie D, Shi J, Fu L, Li Y, Y, Y. Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. J Am Soc Nephrol. 2008, 19(4), 714-21.

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