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张健
2019-06-11 19:13   审核人:   (访问量)

   

   

    张健,女,1983年1月生,副教授,硕士生导师。2011年获澳门新葡8522最新网站细胞生物学专业博士学位。作为课题负责人,主持国家自然科学基金面上项目一项,青年基金一项,教育部博士学科点专项科研基金一项,辽宁省高等学校基本科研项目一项。在cancer letters等国际著名期刊发表多篇SCI论文。参与获得辽宁省科技进步二等奖。研究方向:肿瘤信号转导与靶向药物筛选。承担留学生、研究生、七年制、五年制及生物技术专业本科生的“细胞生物学”及“肿瘤细胞分子生物学”的教学工作。

 

代表性论著:

1. Weiwei Sheng, Chuanping Chen, Ming Dong*, Guosen Wang, Jianping Zhou, He Song, Yang Li, Jian Zhang, Shuangning Ding, Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway, Cell Death Dis. 2017, 8(10): e3147 (IF=5.965)

2. Xu Liu, Qiongyu Duan, Jian Zhang*, Quantitative assessment of lncRNA HOTAIR polymorphisms and cancer risk in Chinese population: a meta-analysis based on 26,810 subjects, Oncotarget, 2017, 8(35): 59698~59708 (IF=5.168)

3. Hongyan Zhang, Jian Zhang, Chenzhou Hao, Ying Zhou, Jian Wang, Maosheng Cheng, Dongmei Zhao, Feng Li*, LC-0882 targets PAK4 and inhibits PAK4-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells, Am J Transl Res, 2017, 9(6): 2736–2747(IF=2.829)

4. Chenzhou Hao, Xiaodong Li, Shuai Song, Bingyu Guo, Jing Guo, Jian Zhang, Qiaoling Zhang, Wanxu Huang, Jian Wang, Bin Lin, Maosheng Cheng*, Feng Li*, Dongmei Zhao*, Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion, Org Biomol Chem, 2016, 14(32): 7676-7690(IF=3.564)

5. Jian Zhang*, Xu Liu, Lianghao You, Ruizhi Zhou, Significant association between long non-coding RNA HOTAIR polymorphisms and cancer susceptibility: a meta-analysis, Onco Targets Ther, 2016, 9: 3335–3343(IF=2.612)

6. Jian Zhang, Hongyan Zhang, Jian Wang, Lianghao You, Ruizhi Zhou, Dongmei Zhao, Maosheng Cheng, Feng Li*, GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways, Int J Mol Sci, 2016, 17(4): 470(IF=3.226)

7. Qiqiang Guo, Nan Su, Jian Zhang, Xiaodong Li, Zhifeng Miao, Guiling Wang, Maosheng Cheng, Huimian Xu, Liu Cao, Feng Li*, PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis, Oncogene, 2014, 33(25): 3277-3287(IF=8.459)

8. Jian Zhang, Jian Wang, Qiqiang Guo, Yu Wang, Ying Zhou, Huizhi Peng, Maosheng Cheng, Dongmei Zhao*, Feng Li*, LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells, Cancer Lett, 2012, 317(1): 24-32(IF=4.258)

9. Yan Li, Yangguang Shao, Yuxin Tong, Tao Shen, Jian Zhang, Yanshu Li, Hui Gu, Feng Li*, Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling, Biochim Biophys Acta-Mol Cell Res, 2012, 1823(2):465-475(IF=4.808)

10. Yangguang Shao, Yan Li, Jian Zhang, Di Liu, Furong Liu, Yue Zhao, Tao Shen, Feng Li*, Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX, Nucleic Acids Res, 2010, 38(9): 2813–2824(IF=7.836)

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